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Would you mind to try Nginx caching in Plesk Onyx 17.8 Preview?
This would be very helpful to get your experienced feedback here http://www.surveygizmo.com/s3/4165754/Plesk-17-8-Preview
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Unless I'm mistaken, I believe Varnish is more of a caching mechanism whereas Nginx is a higher performance HTTP server than Apache (please correct if I'm wrong here). It was my understanding that Varnish was higher performance than Nginx because it can cache entire web pages so that the DB server and PHP for example do not have to be hit on every request. It also features things like Edge Side Includes and ways of purging the cache using a PURGE HTTP request which is pretty nice from a developer point of view. It's great for high traffic sites, but needs quite a bit of extra configuration for each website it caches I believe. The question is: could Nginx be configured per domain to have some of the features that Varnish seems to offer?